Effects of motor imagery-based neurofeedback training after bilateral repetitive transcranial magnetic stimulation on post-stroke upper limb motor function: an exploratory crossover clinical trial.

OBJECTIVE: To examine the clinical effects of combining motor imagery-based neurofeedback training with bilateral repetitive transcranial magnetic stimulation for upper limb motor function in subacute and chronic stroke. DESIGN: Clinical trial following an AB/BA crossover design with counterbalanced assignment. SUBJECTS: Twenty individuals with subacute (n = 4) or chronic stroke (n = 16). METHODS: Ten consecutive sessions of bilateral repetitive transcranial magnetic stimulation alone (therapy A) were compared vs a combination of10 consecutive sessions of bilateral repetitive transcranial magnetic stimulation with 12 non-consecutive sessions of motor imagery-based neurofeedback training (therapy B). Patients received both therapies (1-month washout period), in sequence AB or BA. Participants were assessed before and after each therapy and at 15-days follow-up, using the Fugl-Meyer Assessment-upper limb, hand-grip strength, and the Nottingham Sensory Assessment as primary outcome measures. RESULTS: Both therapies resulted in improved functionality and sensory function. Therapy B consistently exhibited superior effects compared with therapy A, according to Fugl-Meyer Assessment and tactile and kinaesthetic sensory function across multiple time-points, irrespective of treatment sequence. No statistically significant differences between therapies were found for hand-grip strength. CONCLUSION: Following subacute and chronic stroke, integrating bilateral repetitive transcranial magnetic stimulation and motor imagery-based neurofeedback training has the potential to enhance functional performance compared with using bilateral repetitive transcranial magnetic stimulation alone in upper limb recovery.

Perception of Bullying in Early Childhood Education in Spain: Pre-School Teachers vs. Psychologists.

In this work, quantitative research is carried out on the perceptions of early childhood education teachers and child psychologists about the incidence of bullying behaviors in early childhood education (3 to 6 years old) and their knowledge and experience in this regard. For this purpose, two questionnaires were used, each of them oriented to one of the two groups of professionals analyzed, whose answers were subjected to statistical analysis. As for results, it has been obtained that early childhood education teachers express having received deficient training in school bullying and have little experience in its detection and treatment. Furthermore, the teachers' conception of bullying occurring in their own schools is not realistic and differs from the knowledge they have of the existence of bullying behavior in other schools. Likewise, the existence of action plans against bullying in the school conditions the teachers' assessments. The assessments held by psychologists differ significantly from those of teachers, mainly in the identification of the origin of bullying (which teachers attribute to the use of digital technologies and psychologists to the social and family environment of the aggressor). Finally, some implications and recommendations in terms of the training of educational professionals on bullying and the need for greater collaboration between teachers and psychologists are reported.

Impact of Using Facemasks on Literacy Learning: The Perception of Early Childhood Education Teachers.

In this work, quantitative research is carried out on the importance that educators give to literacy work in early childhood education classrooms and the impact that the COVID-19 pandemic and the use of facemasks have had on it. To this end, a survey designed for this purpose has been used, which has been passed on to a set of 112 Spanish early childhood educators. The teachers surveyed occupy different positions in the classroom (tutors, support technicians, specialists in bilingualism, therapeutic pedagogy and speech and hearing), and, in addition, they themselves learned to read from different methods of literacy learning (synthetic or analytical). The results found in this study indicate that educators express intermediate evaluations of the importance of literacy work in the classroom, higher if it is done through digital resources, and higher for the synthetic method than for the analytical method. In addition, the impact of the use of masks on literacy learning was rated as very negative. On the other hand, gaps have been identified in the above perceptions by the position occupied in the classroom and by the method used to learn to read. Finally, some actions are suggested to homogenize the perceptions of the different professionals, and some lines of research are proposed.

Challenging stereotypes of teens: Reframing adolescence as window of opportunity.

In this review, we seek to challenge negative stereotypes of adolescence and unpack the many ways that the developing brain contributes to positive development during the adolescent years. In particular, we will show that risk-taking is not inevitable and risks can be highly adaptive and positive; adolescents are not overly self-centered but engage in other-oriented prosocial behaviors in remarkable ways; adolescents are not only susceptible to negative peer influence but can resist negative peer influence and conform more to positive peer influence; and adolescents do not orient away from the family, but the family remains a constant and important source of influence into adolescence. We outline considerations that researchers can use to reframe their research questions to provide a more balanced perspective on adolescent development, thereby promoting positive development. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Thermophilic (55 °C) and hyper-thermophilic (70 °C) anaerobic digestion as novel treatment technologies for concentrated black water.

Thermophilic and hyper-thermophilic anaerobic digestion (AD) are promising techniques for the treatment of concentrated black water (toilet fraction of domestic wastewater collected by low flush volume toilets; BW), recovery of nutrients and simultaneous pathogen removal for safe recovery and reuse of those nutrients. This study showed that thermophilic AD (55 °C) of concentrated BW reaches the same methanisation and COD removal as mesophilic anaerobic treatment of BW (conventional vacuum toilets) and kitchen waste while applying a higher loading rate (OLR) (2.5-4.0 kgCOD/m3/day). With a retention time of 8.7 days, and an OLR of >3 kgCOD/m3/day, COD removal of 70% and a methanisation of 62% (based on CODt) was achieved during thermophilic AD. Hyper-thermophilic (70 °C) reached lower levels of methanisation (38%). Start-up time of thermophilic AD was 12 days. And during thermophilic AD, a shift from acetoclastic methanogenesis towards syntrophic acetate oxidation was observed.

Selected phytotoxins and organic extracts from endophytic fungus Edenia gomezpompae as light reaction of photosynthesis inhibitors.

In a search for natural herbicides, we investigated the action mechanism of the naphthoquinone spiroketals, isolated from the endophytic fungus Edenia gomezpompae: preussomerins EG1 (1) and EG4 (2), and palmarumycins CP17 (3), and CP2 (4) on the photosynthesis light reactions. The naphthoquinone spiroketals 1-4 inhibited the ATP synthesis in freshly lysed spinach thylakoids from water to MV, and they also inhibited the non-cyclic electron transport in the basal, phosphorylating and uncoupled conditions from water to MV. Therefore, they act as Hill reaction inhibitors. The results suggested that naphthoquinone spiroketals 1-4 have two interactions and inhibition site on the PSII electron transport chain. The first one involves the water splitting enzyme inhibition; and, the second on the acceptor site of PSII in a similar way that herbicide Diuron, studied by polaroghaphy and corroborated by fluorescence of the chlorophyll a of PSII. The culture medium and mycelium organic extracts from four morphological variants of E. gomezpompae were phytotoxic, and the culture medium extracts were more potent than mycelium extracts. They also act as Hill reaction inhibitors.

Genotyping of the MTL loci and susceptibility to two antifungal agents of Candida glabrata clinical isolates.

The opportunistic fungal pathogen Candida glabrata is the second most common isolate from bloodstream infections worldwide and is naturally less susceptible to the antifungal drug fluconazole than other Candida species. C. glabrata is a haploid yeast that contains three mating-type like loci (MTL), although no sexual cycle has been described. Strains containing both types of mating information at the MTL1 locus are found in clinical isolates, but it is thought that strains containing type a information are more common. Here we investigated if a particular combination of mating type information at each MTLlocus is more prevalent in clinical isolates from hospitalized patients in Mexico and if there is a correlation between mating information and resistance to fluconazole and 5-fluorocytosine. We found that while both types of information at MTL1 are equally represented in a collection of 64 clinical isolates, the vast majority of isolates contain a-type information at MTL2 and alpha-type at MTL3. We also found no correlation of the particular combination of mating type information at the three MTL loci and resistance to fluconazole.

Genotyping of the MTL loci and susceptibility to two antifungal agents of Candida glabrata clinical isolates

The opportunistic fungal pathogen Candida glabrata is the second most common isolate from bloodstream infections worldwide and is naturally less susceptible to the antifungal drug fluconazole than other Candida species. C. glabrata is a haploid yeast that contains three mating-type like loci (MTL), although no sexual cycle has been described. Strains containing both types of mating information at the MTL1 locus are found in clinical isolates, but it is thought that strains containing type a information are more common. Here we investigated if a particular combination of mating type information at each MTLlocus is more prevalent in clinical isolates from hospitalized patients in Mexico and if there is a correlation between mating information and resistance to fluconazole and 5-fluorocytosine. We found that while both types of information at MTL1 are equally represented in a collection of 64 clinical isolates, the vast majority of isolates contain a-type information at MTL2 and α-type at MTL3. We also found no correlation of the particular combination of mating type information at the three MTL loci and resistance to fluconazole.

[Severe bronchiolitis. Epidemiology and clinical course of 284 patients]. / Bronquiolitis grave. Epidemiología y evolución de 284 pacientes.

INTRODUCTION: Bronchiolitis is the leading cause of hospital admission and a frequent cause of pediatric intensive care unit (PICU) admission among infants during the winter months. The objective of this study was to analyze the characteristics and clinical course of patients admitted to the PICU for bronchiolitis. PATIENTS AND METHOD: We performed a descriptive, observational study by clinical chart review of all patients admitted to the PICU for severe bronchiolitis from November 1994 to March 2006. RESULTS: A total of 284 patients were included. Most were admitted during December and January and 74% had respiratory syncytial virus (RSV) infection. At least one risk factor for severe disease was present in 68% of the patients: the most frequent risk factor was age < 6 weeks (45%), followed by prematurity (30%). Mechanical ventilation was required in 64 of the 284 patients (24%). Mortality was 1.8% and was associated with chronic pre-existing illness (p < 0.001). The factors associated with a greater risk of mechanical ventilation and a longer PICU stay were the association of two or more risk factors (42/284; 15%), the presence of apnea (73/284; 25.7%), and images of pulmonary consolidation or atelectasis on admission chest X-ray (157/284; 55%). CONCLUSIONS: Most patients admitted for severe bronchiolitis to the PICU are healthy infants whose principal risk factor is young age. The main predictors of severe clinical course during PICU stay are the association of two or more risk factors, the presence of apnea, and pulmonary consolidation on admission chest X-ray. Bronchiolitis-associated mortality is low and is associated with pre-existing chronic illness.